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1994 1
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2007 1
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2012 3
2013 7
2014 9
2015 7
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2017 11
2018 13
2019 10
2020 18
2021 15
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2024 5

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119 results

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Exercise-activated hepatic autophagy via the FN1-alpha5beta1 integrin pathway drives metabolic benefits of exercise.
Kuramoto K, Liang H, Hong JH, He C. Kuramoto K, et al. Cell Metab. 2023 Apr 4;35(4):620-632.e5. doi: 10.1016/j.cmet.2023.01.011. Epub 2023 Feb 21. Cell Metab. 2023. PMID: 36812915 Free PMC article.
Muscle-secreted FN1 mediates exercise-induced hepatic autophagy and systemic insulin sensitization via the hepatic receptor alpha5beta1 integrin and the downstream IKKalpha/beta-JNK1-BECN1 pathway. Thus, we demonstrate that hepatic autophagy activation drives exercise-indu …
Muscle-secreted FN1 mediates exercise-induced hepatic autophagy and systemic insulin sensitization via the hepatic receptor alpha5bet …
RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells.
Zhang Z, Guo M, Li Y, Shen M, Kong D, Shao J, Ding H, Tan S, Chen A, Zhang F, Zheng S. Zhang Z, et al. Autophagy. 2020 Aug;16(8):1482-1505. doi: 10.1080/15548627.2019.1687985. Epub 2019 Nov 11. Autophagy. 2020. PMID: 31679460 Free PMC article.
In mice, treatment with erastin and sorafenib alleviated murine liver fibrosis by inducing HSC ferroptosis. HSC-specific overexpression of Zfp36 impaired erastin- or sorafenib-induced HSC ferroptosis. ...Overall, these results revealed novel molecular mechanisms and signal …
In mice, treatment with erastin and sorafenib alleviated murine liver fibrosis by inducing HSC ferroptosis. HSC-specific overexpressi …
Anti-Liver Fibrosis Role of miRNA-96-5p via Targeting FN1 and Inhibiting ECM-Receptor Interaction Pathway.
Zhang Y, Gu T, Xu S, Wang J, Zhu X. Zhang Y, et al. Appl Biochem Biotechnol. 2023 Nov;195(11):6840-6855. doi: 10.1007/s12010-023-04385-1. Epub 2023 Mar 21. Appl Biochem Biotechnol. 2023. PMID: 36943602
Downregulation of the expression of the FN1 gene by transfecting with FN1-siRNA alleviated the activity of HSCs. ...Additionally, miR-96-5p expression was low in CCl4-induced liver fibrosis mice. Increased miR-96-5p expression alleviated liver fibrosis …
Downregulation of the expression of the FN1 gene by transfecting with FN1-siRNA alleviated the activity of HSCs. ...Additional …
Prognostic Significance of CDH1, FN1 and VIM for Early Recurrence in Patients with Colorectal Liver Metastasis After Liver Resection.
Bogdanovic A, Despotovic J, Galun D, Bidzic N, Nikolic A, Rosic J, Krivokapic Z. Bogdanovic A, et al. Cancer Manag Res. 2021 Jan 11;13:163-171. doi: 10.2147/CMAR.S287974. eCollection 2021. Cancer Manag Res. 2021. PMID: 33469360 Free PMC article.
PURPOSE: There are limited data on expression of epithelial-mesenchymal transition (EMT) markers in patients with colorectal liver metastases (CRLM). The study aim was to evaluate the expression and prognostic significance of E-cadherin (CDH1), fibronectin (FN1) and …
PURPOSE: There are limited data on expression of epithelial-mesenchymal transition (EMT) markers in patients with colorectal liver me …
Single-cell dissection of remodeled inflammatory ecosystem in primary and metastatic gallbladder carcinoma.
Wang X, Liu C, Chen J, Chen L, Ren X, Hou M, Cui X, Jiang Y, Liu E, Zong Y, Duan A, Fu X, Yu W, Zhao X, Yang Z, Zhang Y, Fu J, Wang H. Wang X, et al. Cell Discov. 2022 Oct 5;8(1):101. doi: 10.1038/s41421-022-00445-8. Cell Discov. 2022. PMID: 36198671 Free PMC article.
We further pinpointed a subset of senescence-like fibroblasts (FN1(+)TGM2(+)) preferentially enriched in metastatic lesions, which promoted GBC migration and invasion via their secretory phenotype. ...
We further pinpointed a subset of senescence-like fibroblasts (FN1(+)TGM2(+)) preferentially enriched in metastatic lesions, which pr …
Fibrogenic signals persist in DAA-treated HCV patients after sustained virological response.
Montaldo C, Terri M, Riccioni V, Battistelli C, Bordoni V, D'Offizi G, Prado MG, Trionfetti F, Vescovo T, Tartaglia E, Strippoli R, Agrati C, Tripodi M. Montaldo C, et al. J Hepatol. 2021 Dec;75(6):1301-1311. doi: 10.1016/j.jhep.2021.07.003. Epub 2021 Jul 13. J Hepatol. 2021. PMID: 34271004 Free article.
CONCLUSIONS: Taken together, these results highlight structural EV modifications that are conceivably causal for long-term liver disease progression in patients with HCV despite DAA-mediated SVR. ...Herein, we show that extracellular vesicle modifications could be linked t …
CONCLUSIONS: Taken together, these results highlight structural EV modifications that are conceivably causal for long-term liver dise …
Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers.
Furuta M, Tanaka H, Shiraishi Y, Unida T, Imamura M, Fujimoto A, Fujita M, Sasaki-Oku A, Maejima K, Nakano K, Kawakami Y, Arihiro K, Aikata H, Ueno M, Hayami S, Ariizumi SI, Yamamoto M, Gotoh K, Ohdan H, Yamaue H, Miyano S, Chayama K, Nakagawa H. Furuta M, et al. Oncotarget. 2018 May 18;9(38):25075-25088. doi: 10.18632/oncotarget.25308. eCollection 2018 May 18. Oncotarget. 2018. PMID: 29861854 Free PMC article.
We conducted an HBV sequence capture, followed by ultra-deep sequencing, to screen for HBV integrations in 111 liver samples from human-hepatocyte chimeric mice with HBV infection and human clinical samples containing 42 paired samples from non-tumorous and tumorous liv …
We conducted an HBV sequence capture, followed by ultra-deep sequencing, to screen for HBV integrations in 111 liver samples from hum …
Induced Endothelial Cell-Integrated Liver Assembloids Promote Hepatic Maturation and Therapeutic Effect on Cholestatic Liver Fibrosis.
Nam D, Park MR, Lee H, Bae SC, Gerovska D, Araúzo-Bravo MJ, Zaehres H, Schöler HR, Kim JB. Nam D, et al. Cells. 2022 Jul 19;11(14):2242. doi: 10.3390/cells11142242. Cells. 2022. PMID: 35883684 Free PMC article.
Liver assembloids showed enhanced functional maturity compared to iHLOs in vitro and improved therapeutic effects on cholestatic liver fibrosis animals in vivo. Mechanistically, FN1 expressed from iECs led to the upregulation of Itgalpha5/beta1 and Hnf4alpha …
Liver assembloids showed enhanced functional maturity compared to iHLOs in vitro and improved therapeutic effects on cholestatic l …
Osr1 regulates hepatic inflammation and cell survival in the progression of non-alcoholic fatty liver disease.
Zhou Y, Liu Z, Lynch EC, He L, Cheng H, Liu L, Li Z, Li J, Lawless L, Zhang KK, Xie L. Zhou Y, et al. Lab Invest. 2021 Apr;101(4):477-489. doi: 10.1038/s41374-020-00493-2. Epub 2020 Oct 1. Lab Invest. 2021. PMID: 33005011 Free PMC article.
Following 12 weeks of diethylnitrosamine (DEN) and high-fat diet (HFD), wildtype (WT) and Osr1 heterozygous (Osr1(+/-)) male mice were examined for liver injuries. Osr1(+/-) mice displayed worsen liver injury with higher serum alanine aminotransferase levels than th …
Following 12 weeks of diethylnitrosamine (DEN) and high-fat diet (HFD), wildtype (WT) and Osr1 heterozygous (Osr1(+/-)) male mice were exami …
Hepatoprotective Effects of Hyaluronic Acid-Preconditioned Bone Marrow Mesenchymal Stem Cells against Liver Toxicity via the Inhibition of Apoptosis and the Wnt/beta-Catenin Signaling Pathway.
Awadalla A, Hamam ET, Mostafa SA, Mahmoud SA, Elazab KM, El Nakib AM, Eldesoqui M, El-Sherbiny M, Ammar OA, Al-Serwi RH, Saleh MA, Sarhan A, Ali M. Awadalla A, et al. Cells. 2023 Jun 1;12(11):1526. doi: 10.3390/cells12111526. Cells. 2023. PMID: 37296647 Free PMC article.
OBJECTIVES: This study investigated whether bone BMSCs could reduce DOX-induced liver damage by blocking the Wnt/beta-catenin pathway that causes fibrotic liver. ...Morphological and immunohistochemical observations were also carried out. RESULTS: In terms of liv …
OBJECTIVES: This study investigated whether bone BMSCs could reduce DOX-induced liver damage by blocking the Wnt/beta-catenin pathway …
119 results